Laboratory of Cell Behavior

Our goal is to understand how cells regulate their behavior in health and disease.

We focus on some of the most dramatic cell behaviors – cell death, migration, and engulfment (phagocytosis). These behaviors are essential for normal development and tissue homeostasis, and they go awry in many diseases.

Dying cell · engulfing cells
Approach

From a living organism to human disease

We study single cells within the physiological context of a living, multicellular organism, and translate our findings to human disease. To do this, we take a multi-system approach that combines work in C. elegans, cultured cells, and human tissues.

C. elegans
01 C. elegans Discovery in a living, multicellular organism
Mouse
02 Cultured cells Testing conservation in mammalian systems
Human
03 Human tissues Toward therapeutic strategies for cancer and other diseases
Research questions
01

Developmental cell death

How is developmental cell death regulated? How is it dysregulated in disease?

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02

Cell migration

What intrinsic factors regulate single cell migration?

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03

Cell engulfment

How do dying and engulfing cells communicate?

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Cold Spring Harbor Laboratory campus by the harbor in autumn
Cold Spring Harbor Laboratory
Affiliation

CSHL–Northwell Health

The Yarychkivska Lab is part of the Cold Spring Harbor Laboratory–Northwell Health research community, where basic discovery meets clinical research.

This environment gives us access to leading-edge technologies, a strong foundation in fundamental biology, and close connections to physicians and patient-derived material.

Join our laboratory

We are hiring

We are recruiting a research assistant, a postdoc, and welcome graduate and undergraduate students.

Contact us